/* this is the new main.css file */
#wrapper {
    max-width: 1345px;
    margin: 0 auto;
    position: relative;
    background: #fff;
    overflow: hidden;
    padding: 0;
}
.holder {
    max-width: 1350px;
    margin: 0 auto;
    padding: 0 20px;
}
.left, .right {
    float: left;
}
.left {
    width: 35%;
    padding:60px 75px 0 30px;
}
.right {
    width: 63%;
    margin-top: -230px;
}
.right.wife {
    width: 63%;
    margin-top: -105px;
}
.subscription-form .row.select-row {
    margin-bottom: 14px;
}
.select-row span {
    font-size: 18px;
}
.visual {
    background-position: center center;
    background-image: url("http://image.medicalupdate.novartis.at/lib/fe9213737762077f73/m/1/7f27f1f8-c529-4c46-b9e3-b70238b617b5.jpg");
    min-height: 538px;
    background-repeat: no-repeat;
    background-size: cover;
}
.visual.info {
    background-image: url("http://image.medicalupdate.novartis.at/lib/fe9213737762077f73/m/1/78778fc1-67b3-45c1-b4a4-27277f3a99e5.jpg");
}
.visual-grey {
    background-color: #C6C6C6;
    width: 100%;
}
.visual-white {
    background-color: white;
    width: 100%;
    font-size: 18px;
}
.visual-white h1{
    padding: 93px 44px 11px 109px;
    margin-top: 14px;
}
.subscription-page .visual-white h3{
    padding: 93px 44px 11px 109px;
    margin-top: 14px;
    font-size: 36px;
    line-height: 38px;
}
.visual-white p, .visual-white ul{
    padding: 10px 44px 13px 109px;
    line-height: 28px;
    font-size: 18px;
}
.visual-white p.onlyonce{
    padding-left: 37px;
    padding-top: 0;
}
.visual-white form{
    padding-left: 37px;
    padding-top: 1px;
}
.visual-white p.clink {
    position: relative;
    left: -48px;
}
.visual-white a {
    color: #8D1F1B;
    text-decoration: none;
}
a.arrowclink {
    background: url(http://image.medicalupdate.novartis.at/lib/fe9213737762077f73/m/1/f865a26c-8b79-4f26-930d-93afb4999fcc.png);
    background-repeat: no-repeat;
    background-position: left;
    padding:45px;
}
.visual-brown {
    background-color: #5E1619;
    width: 92%;
    position: relative;
    top: 62px;
    left: 8%;
}
.right.wife .visual-brown h3 {
    color: white;
    padding: 13px 2px 0 20px;
    
}    
.visual .img-holder img {
    display: block;
    width: 100%;
    height: auto;
    min-height: 95px;
}
.visual-holder {
    margin: -47px 0 10px;
}
.visual-holder .btn-holder {
    max-width: 290px;
}
.visual-holder .btn-holder a {
    font-weight: bold;
    text-transform: uppercase;
    font-size: 15px;
    text-decoration: none;
    display: block;
    vertical-align: top;
    border: 3px solid #dee2e7;
    padding: 7px 7px 4px;
    color: #7d8aa2;
    -webkit-transition: all .2s ease-in-out;
    transition: all .2s ease-in-out;
}
.visual-holder .btn-holder a:hover {
    box-shadow: inset 1px 1px 4px 1px rgba(0, 0, 0, .2);
}
.visual-holder .btn-holder span {
    display: inline-block;
    vertical-align: middle;
    padding: 0 5px;
}
.content-holder {
    line-height: 25px;
}
.content-holder p {
    margin: 0 0 25px;
}
.visual-box {
    position: relative;
    z-index: 3;
    display: inline-block;
    vertical-align: top;
    box-shadow: inset 1px 2px 10px 0 rgba(0, 0, 0, .25), 1px 2px 10px 0 rgba(0, 0, 0, .25);
}
.visual-text {
    display: inline-block;
    font-weight: bold;
    padding: 20px 50px;
}
.visual-text p {
    display: block;
    font-size: 36px;
    color: white;    
    margin-bottom: 12px;
    line-height: 40px;
}
ul.list-sign {
    margin-top: 50px;
    padding: 0;
}
ul.list-sign li{
    padding-bottom: 30px;
    background: url(http://image.medicalupdate.novartis.at/lib/fe9213737762077f73/m/1/203c5f84-5368-4b76-a744-ec9d5a0adb01.png) no-repeat left top;
    padding: 26px 1px 12px 49px;
    /* reset styles (optional): */
    list-style: none;
    margin: 0;
}
ul.list-sign li p {
    font-size: 18px;
    margin-top: -30px;
}
.nav-drop {
    position: absolute;
    left: 0;
    top: 88px;
    background: #fcfcfd;
    width: 100%;
    visibility: hidden;
    opacity: 0;
    -webkit-transition: all .3s ease-in-out;
    transition: all .3s ease-in-out;
    min-height: 9999px;
}
.nav-drop .ico-holder {
    display: inline-block;
    vertical-align: middle;
    max-width: 50px;
    min-height: 36px;
    margin: 0 0 0 auto;
}
.nav-drop .ico-holder.last img {
    display: block;
    width: 90%;
}
.nav-drop .ico-holder.pre-last img {
    display: block;
    width: 95%;
}
.nav-drop li {
    color: #465265;
    font-size: 16px;
    text-align: center;
}
.nav-drop li:last-child a:before {
    display: none;
}
.nav-drop a {
    color: inherit;
    display: block;
    padding: 19px 10px 15px 20px;
    font-weight: bold;
    text-decoration: none;
    -webkit-transition: color,background ease .3s;
    transition: color,background ease .3s;
    position: relative;
}
.nav-drop a:hover {
    color: #465265;
    background: transparent;
}
.nav-drop a:hover:after {
    opacity: 1;
    visibility: visible;
}
.nav-drop a:before {
    content: "";
    position: absolute;
    bottom: 0;
    left: 0;
    width: 100%;
    background: #dce0e5 -webkit-linear-gradient(left, #f9fafb 0%, #f2f4f6 36%, #f2f4f6 36%, #dce0e5 100%);
    background: #dce0e5 linear-gradient(to right, #f9fafb 0%, #f2f4f6 36%, #f2f4f6 36%, #dce0e5 100%);
    height: 1px;
}
.nav-drop a:after {
    content: "";
    position: absolute;
    display: block;
    width: 100%;
    left: 0;
    top: 0;
    bottom: 0;
    background: rgba(92, 109, 137, .3);
    opacity: 0;
    visibility: hidden;
}
.nav-active .nav-drop {
    height: auto;
    opacity: 1;
    visibility: visible;
    z-index: 99;
}
.resize-active .nav-drop {
    -webkit-transition: none !important;
    transition: none !important;
}
.link-text {
    display: inline-block;
    vertical-align: middle;
    padding-right: 20px;
    min-width: 250px;
    text-align: left;
}
.nav-opener {
    box-shadow: 1px 1px 8px 1px rgba(0, 0, 0, .2);
    position: absolute;
    z-index: 999;
    top: 10px;
    right: 0;
    width: 88px;
    height: 66px;
    text-indent: -9999px;
    overflow: hidden;
}
.nav-opener:before,
.nav-opener:after,
.nav-opener span {
    background: #7d8aa1;
    position: absolute;
    top: 31px;
    left: 22px;
    right: 3px;
    width: 44px;
    height: 5px;
    -webkit-transition: all .2s linear;
    transition: all .2s linear;
}
.nav-opener:before,
.nav-opener:after {
    content: "";
    top: 19px;
}
.nav-opener:after {
    top: 43px;
}
.nav-opener:hover:before,
.nav-opener:hover:after,
.nav-opener:hover span,
.nav-opener:focus:before,
.nav-opener:focus:after,
.nav-opener:focus span {
    background: #8D1F1B;
    outline: none;
}
.nav-active .nav-opener span {
    opacity: 0;
}
.nav-active .nav-opener:after,
.nav-active .nav-opener:before {
    -webkit-transform: rotate(45deg);
    -ms-transform: rotate(45deg);
    transform: rotate(45deg);
    top: 30px;
    left: 24%;
    right: 10%;
    background: #7d8aa1;
}
.nav-active .nav-opener:after {
    -webkit-transform: rotate(-45deg);
    -ms-transform: rotate(-45deg);
    transform: rotate(-45deg);
}
.title {
    text-align: center;
    padding: 22px 20px 15px;
    box-shadow: 0 -1px 6px 0 rgba(0, 0, 0, .15);
}
.title h1 {
    color: #8D1F1B;
    font-weight: normal;
    margin: 0 0 10px;
    text-transform: uppercase;
}
.title img {
    display: inline-block;
    vertical-align: middle;
    margin-right: 15px;
}
.title img.summary-ico {
    display: block;
    margin: 0 auto 10px;
    display: inline-block;
    vertical-align: middle;
    margin-right: 15px;
}
.slideshow-holder {
    box-shadow: 2px 2px 6px 0 rgba(0, 0, 0, .2);
}
.slideshow-top {
    position: relative;
}
.slideshow-top .slide {
    position: absolute;
    z-index: 1;
    left: 0;
    top: 0;
    width: 100%;
    background-size: cover;
    padding: 46px 30px 70px;
    min-height: 320px;
}
.slideshow-top .slide.active {
    z-index: 2;
}
.slideshow-top .slide-text {
    font-size: 18px;
    line-height: 27px;
    max-width: 460px;
    margin: 0 auto;
    display: block;
    color: #5c6d89;
    text-align: center;
}
.pagination,
.slick-dots {
    position: absolute;
    bottom: 38px;
    left: 50%;
    -webkit-transform: translateX(-50%);
    -ms-transform: translateX(-50%);
    transform: translateX(-50%);
    z-index: 10;
}
.pagination ul,
.slick-dots ul {
    text-align: center;
}
.pagination li,
.slick-dots li {
    display: inline-block;
    vertical-align: top;
    width: 13px;
    height: 13px;
    margin-right: 9px;
    border-radius: 50%;
    text-indent: 9999px;
    overflow: hidden;
    border: 3px solid #a7b1bf;
}
.pagination li.active,
.slick-dots li.active,
.pagination li:hover,
.slick-dots li:hover {
    background: #5c6d89;
    border-color: #5c6d89;
}
.pagination a,
.slick-dots a {
    display: block;
    height: 100%;
}
.btn-next,
.slick-next,
.btn-prev,
.slick-prev {
    position: absolute;
    z-index: 50;
    bottom: 38px;
    left: 23px;
    text-indent: -9999px;
}
.btn-next:before,
.slick-next:before,
.btn-prev:before,
.slick-prev:before {
    content: "";
    display: block;
    position: absolute;
    top: 0;
    width: 14px;
    height: 14px;
    -webkit-transform: rotate(45deg);
    -ms-transform: rotate(45deg);
    transform: rotate(45deg);
    border-left: 2px solid #a7b0bf;
    border-bottom: 2px solid #a7b0bf;
    -webkit-transition: border-color .3s ease-in-out;
    transition: border-color .3s ease-in-out;
}
.btn-next:hover:before,
.slick-next:hover:before,
.btn-prev:hover:before,
.slick-prev:hover:before {
    border-color: #8D1F1B;
}
.btn-next:focus:before,
.slick-next:focus:before,
.btn-prev:focus:before,
.slick-prev:focus:before {
    border-color: #5c6d89;
}
.btn-next,
.slick-next {
    left: auto;
    right: 40px;
}
.btn-next:before,
.slick-next:before {
    -webkit-transform: rotate(-135deg);
    -ms-transform: rotate(-135deg);
    transform: rotate(-135deg);
}
.content-section .holder {
    padding-top: 35px;
}
.content-section .img-holder {
    margin-bottom: 45px;
}
.popup-holder {
    background: #fff;
    border: 1px solid #d8d8d8;
    border-radius: 5px;
    padding: 6px;
    display: inline-block;
    vertical-align: top;
    position: relative;
    margin-bottom: 20px;
    box-shadow: 1px 1px 8px 1px rgba(0, 0, 0, .2);
}
.popup-holder img {
    display: block;
    width: 100%;
    height: auto;
}
.popup-holder .ico-holder {
    position: absolute;
    bottom: 0;
    right: 5px;
}
.popup-holder a {
    display: block;
    position: relative;
}
.lightbox {
    display: none;
}
.add-info-box {
    text-transform: uppercase;
    font-weight: bold;
    color: #5c6d89;
    border: 4px solid #dee2e7;
    display: inline-block;
    max-width: 645px;
    margin-left: -65px;
    padding: 12px 20px 14px 62px;
    font-size: 18px;
    line-height: 23px;
    margin-bottom: 26px;
    box-shadow: 2px 2px 4px 0 rgba(222, 226, 231, .25), inset 2px 2px 5px 0 rgba(222, 226, 231, .25);
}
.add-info-box.large {
    margin-bottom: 50px;
    max-width: 850px;
}
.content-block {
    line-height: 25px;
}
.content-block p {
    margin: 0 0 26px;
}
.content-block a {
    color: inherit;
}
.content-block a:hover {
    color: #8D1F1B;
    text-decoration: none;
}
.video-holder {
    margin-bottom: 17px;
    box-shadow: 2px 2px 8px 2px rgba(0, 0, 0, .25);
}
.description .img-holder {
    width: 45%;
    display: -webkit-box;
    display: -webkit-flex;
    display: -ms-flexbox;
    display: flex;
}
.description .img-holder img {
    display: block;
    width: 100%;
    height: auto;
}
.description-content {
    background: #355f84;
    color: #fff;
    padding: 10px 20px;
    line-height: 25px;
}
.content-row {
    padding: 25px 0 5px;
}
.content-row + .content-row {
    border-top: 3px solid rgba(255, 255, 255, .1);
}
.content-row p {
    margin: 0 0 17px;
}
.content-row ul {
    font-size: 14px;
    line-height: 20px;
    margin: 0 0 18px;
}
.content-row li {
    position: relative;
    margin: 0 0 12px;
    padding-left: 15px;
}
.content-row li:before {
    content: "";
    position: absolute;
    top: 5px;
    left: 0;
    width: 9px;
    height: 9px;
    border-radius: 50%;
    border: 2px solid #a4b7c8;
}
.bottom-section .holder {
    padding: 25px 0 0;
}
.bottom-section h3 {
    font-size: 25px;
    margin: 0 0 23px 20px;
    color: #374b5a;
}
.bottom-section .opener {
    color: #7c868e;
    display: block;
    padding: 20px 65px 18px 20px;
    border-top: 1px solid #d6dbe1;
    border-bottom: 1px solid #d6dbe1;
    position: relative;
    text-decoration: none;
    font-weight: bold;
    line-height: 25px;
}
.bottom-section .opener:after,
.bottom-section .opener:before {
    content: "";
    position: absolute;
    top: 50%;
    right: 15px;
    z-index: 10;
    margin-top: -2px;
    width: 26px;
    height: 4px;
    background: #ccc;
    -webkit-transition: opacity .3s ease-in-out;
    transition: opacity .3s ease-in-out;
}
.bottom-section .opener:before {
    -webkit-transform: rotate(90deg);
    -ms-transform: rotate(90deg);
    transform: rotate(90deg);
}
.bottom-section .opener:hover {
    color: #374b5a;
    background: #f4f6f7;
}
.bottom-section .opener em {
    position: absolute;
    top: 0;
    right: 0;
    bottom: 0;
    width: 60px;
    background: #fff;
    margin-bottom: -1px;
    border-left: 1px solid #d6dbe1;
    border-bottom: 1px solid #d6dbe1;
}
.open-close .slide {
    padding: 22px 20px 5px;
    line-height: 20px;
}
.open-close .slide p {
    margin: 0 0 20px;
}
.open-close.active .opener {
    color: #374b5a;
    background: #f4f6f7;
}
.open-close.active .opener:before {
    opacity: 0;
    visibility: hidden;
}
.open-close-holder {
    border: 2px solid #ced3db;
    margin: 0 0 45px;
}
.open-close-holder:last-child {
    margin: 0;
}
.open-close-holder.literatur .opener {
    padding-top: 16px;
    padding-bottom: 13px;
}
.open-close-holder.literatur .slide {
    font-size: 14px;
    padding-top: 25px;
    line-height: 22px;
}
.open-close-holder.literatur .slide ol {
    counter-reset: list_item;
}
.open-close-holder.literatur .slide ol li {
    display: block;
    margin: 0 0 22px;
    padding: 0 25px;
    overflow: hidden;
}
.open-close-holder.literatur .slide ol li:before {
    content: "" counter(list_item) ". ";
    counter-increment: list_item;
    color: #abacac;
    float: left;
    margin: 0 0 0 -25px;
    padding: 0;
    width: 16px;
    font-size: 14px/1.2 "Times New Roman", "Times", "Baskerville", "Georgia", serif;
}
.subscription-form {
    padding: 30px;
    padding-top: 50px;
    margin-top: -11px;
}
.subscription-form p {
    line-height: 1.2;
}
.subscription-form .sub-title {
    display: block;
    line-height: 1.2;
    margin: 0 0 1.5em;
}
.subscription-form .row {
    margin: 0 0 15px;
}
.subscription-form label {
    display: block;
    margin: 0 0 5px;
    font-size: 18px;
    font-weight: bold;
}
.subscription-form label em {
    color: black;
    font-style: normal;
}
.subscription-form .text {
    width: 100%;
    color: black;
}
.subscription-form .text::-webkit-input-placeholder {
    color: #9d9d9c;
}
.subscription-form .text::-moz-placeholder {
    opacity: 1;
    color: #9d9d9c;
}
.subscription-form .text:-moz-placeholder {
    color: #9d9d9c;
}
.subscription-form .text:-ms-input-placeholder {
    color: #9d9d9c;
}
.subscription-form .text.placeholder {
    color: #9d9d9c;
}
.subscription-form .text:focus {
    border-color: #9da7b9;
    box-shadow: 0 0 7px rgba(69, 115, 141, .27);
}
.subscription-form .row-check {
    margin: 0 0 15px;
}
.radioleft, .radioright {
    float: left;
    padding-right: 23px;
}
input[type="radio"] { display: none; } 
input[type="radio"] + label { 
    font-size: 18px; 
    font-weight: 500;
    cursor: pointer;
} 
input[type="radio"] + label span { 
    display: inline-block; 
    width: 18px; height: 18px; 
    margin: -5px 6px 0 0; 
    vertical-align: middle; 
    cursor: pointer; 
    -moz-border-radius: 50%; border-radius: 50%; 
    border: 3px solid #ffffff; 
} 
.subscription-form input[type="radio"] + label span { background-color: #fff; } 
.subscription-form input[type="radio"]:checked + label {font-weight: 500; } 
.subscription-form input[type="radio"]:checked + label span { background-color: #5E1619; border: 2px solid #ffffff; box-shadow: 2px 2px 2px rgba(0,0,0,.1); } 
.subscription-form input[type="radio"] + label span, input[type="radio"]:checked + label span { 
    -webkit-transition: background-color 0.24s linear; -o-transition: background-color 0.24s linear; -moz-transition: background-color 0.24s linear; transition: background-color 0.24s linear; 
}
.borderwhite {
    border-top: 1px solid white;
    border-bottom: 1px solid white;
    padding-bottom: 15px;
    padding-top: 24px;
    width: 98%;
}
.subscription-form .row-check [type="checkbox"], #weitereinfos [type="checkbox"] {
    position: fixed;
    left: 0;
    top: 0;
    opacity: 0;
    z-index: -1;
}
.subscription-form .row-check .fake-input,
.subscription-form .row-check label, 
#weitereinfos .fake-input {
    display: inline-block;
    vertical-align: middle;
    margin: 0;
}
.subscription-form .row-check label {
    overflow: hidden;
}
.subscription-form .hidden .row-check label {
    width: 98%;   
}
.subscription-form .row-check a {
    color: #8D1F1B;
    text-decoration: none;
}
.subscription-form .row-check a:hover {
    color: #8D1F1B;
    text-decoration: underline;
}
.subscription-form .row-check .fake-input, #weitereinfos .fake-input{
    float: left;
    width: 18px;
    height: 18px;
    border: 1px solid #bac1ce;
    background: #fff;
    box-shadow: inset 0 1px 2px rgba(65, 69, 76, .2);
    vertical-align: middle;
    position: relative;
    margin-right: 5px;
}
.subscription-form .row-check .fake-label {
    max-width: 90%;
    /* display: none; */
}
.preferencesPage.subscription-form .row-check .fake-label {
    display: none;
}
.preferencesPage.subscription-form select {
    padding: 7px 0;
    background-color: white;
    color: black;
    border: 0;
    width: 76px;
}
.preferencesPage.subscription-form .row.small{
    width: 33%;
}
.preferencesPage.subscription-form .row.medium {
    width: 47%;
} 
.preferencesPage.subscription-form .inner-box P {
    padding-left: 4px;
    font-size: 18px;
    font-weight: bold;
}

.UnsubscribePage P {
    padding-left: 4px;
    font-size: 18px;
    font-weight: bold;
}
.UnsubscribePage.subscription-form {
    padding-top: 98px;
}
.UnsubscribePage textarea {
    width: 90%;
}
.PersonalLocation.subscription-form {
    padding-top: 60px;
}

.PersonalLocation.subscription-form .sub-title{
    display: none;
}
.PersonalLocation.subscription-form P {
    padding-left: 0;
    font-size: 18px;
    font-weight: bold;
}
.PersonalLocation.subscription-form P.onlyonce {
    padding-left: 36px;
   
}

.subscription-form .row-check [type="checkbox"] + .fake-input:before {
    content: "";
    position: absolute;
    top: 50%;
    left: 50%;
    margin: -5px 0 0 -5px;
    background: url(http://image.medicalupdate.novartis.at/lib/fe9213737762077f73/m/1/8be00b20-7073-48b9-be27-b1557619eeff.png) no-repeat;
    width: 10px;
    height: 10px;
    background-size: cover;
    opacity: 0;
}
.subscription-form .row-check [type="checkbox"]:checked + .fake-input:before {
    opacity: 1;
}
.subscription-form .row-check [type="checkbox"]:checked + .fake-input {
    border-color: #9da7b9;
    border-width: 2px;
}
.subscription-form .row-check [type="checkbox"]:checked + .fake-input:before {
    opacity: 1;
}
.subscription-form .row-check input:disabled + .fake-input,
.subscription-form .row-check input:disabled ~ .fake-label {
    opacity: .5;
}
#weitereinfos [type="checkbox"] + .fake-input:before {
    content: "";
    position: absolute;
    top: 50%;
    left: 50%;
    margin: -5px 0 0 -5px;
    background: url(http://image.medicalupdate.novartis.at/lib/fe9213737762077f73/m/1/8be00b20-7073-48b9-be27-b1557619eeff.png) no-repeat;
    width: 10px;
    height: 10px;
    background-size: cover;
    opacity: 0;
}
#weitereinfos[type="checkbox"]:checked + .fake-input:before {
    opacity: 1;
}
#weitereinfos [type="checkbox"]:checked + .fake-input {
    border-color: #9da7b9;
    border-width: 2px;
}
#weitereinfos [type="checkbox"]:checked + .fake-input:before {
    opacity: 1;
}
#weitereinfos input:disabled + .fake-input,
#weitereinfos input:disabled ~ .fake-label {
    opacity: .5;
}







.subscription-form .submit {
    background: #8D1F1B;
    color: #fff;
    border: 0;
    text-align: center;
    width: 100%;
    padding: 10px;
    -webkit-transition: all .2s linear;
    transition: all .2s linear;
    font-weight: bold;
}
.subscription-form .submit:hover {
    opacity: .75;
    -webkit-transition: all .2s linear;
    transition: all .2s linear;
}
.archive-holder .row-link {
    margin: 0 0 10px;
}
.archive-holder .row-link a {
    color: #8D1F1B;
    text-decoration: underline;
    -webkit-transition: all .2s linear;
    transition: all .2s linear;
    font-weight: bold;
}
.archive-holder .row-link a:hover {
    color: #bf7d1a;
    -webkit-transition: all .2s linear;
    transition: all .2s linear;
}
.archive-holder h3 {
    color: #8D1F1B;
    font-size: 23px;
    margin: 0 0 28px;
}
.accordion {
    border: 2px solid #ced3db;
}
.accordion li {
    display: block;
    background: #fff;
}
.accordion li:nth-child(2n) {
    background: #f4f2f0;
    border-bottom: 1px solid #e5e7ea;
}
.accordion li:hover > a,
.accordion li.active > a {
    background: #8D1F1B;
    color: #fff;
    -webkit-transition: all .2s linear;
    transition: all .2s linear;
}
.accordion li:hover > a:after,
.accordion li:hover > a:before,
.accordion li.active > a:after,
.accordion li.active > a:before {
    background: #fff;
}
.accordion li.active a:after {
    background: #fff;
    -webkit-transform: rotate(45deg);
    -ms-transform: rotate(45deg);
    transform: rotate(45deg);
    right: 14px;
    margin: 0;
    -webkit-transition: all .2s linear;
    transition: all .2s linear;
}
.accordion li.active a:before {
    background: #fff;
    margin: 0;
    -webkit-transition: all .2s linear;
    transition: all .2s linear;
}
.accordion li.active ul a:after {
    -webkit-transform: rotate(45deg);
    -ms-transform: rotate(45deg);
    transform: rotate(45deg);
    margin: -2px 0 0;
    right: 10px;
    background: #999;
}
.accordion li.active ul a:before {
    margin: 2px 0 0;
    right: 10px;
    background: #999;
}
.accordion a {
    text-decoration: none;
    color: #000;
    font-weight: bold;
    padding: 8px 15px;
    display: block;
    font-size: 12px;
    -webkit-transition: all .2s linear;
    transition: all .2s linear;
    position: relative;
}
.accordion a:after {
    content: "";
    clear: both;
    display: block;
    position: absolute;
    top: 50%;
    right: 10px;
    width: 8px;
    height: 2px;
    background: #999;
    -webkit-transform: rotate(45deg);
    -ms-transform: rotate(45deg);
    transform: rotate(45deg);
    margin: -2px 0 0;
    -webkit-transition: all .2s linear;
    transition: all .2s linear;
}
.accordion a:before {
    content: "";
    clear: both;
    display: block;
    position: absolute;
    top: 50%;
    right: 10px;
    width: 8px;
    height: 2px;
    margin: 2px 0 0;
    background: #999;
    -webkit-transform: rotate(-45deg);
    -ms-transform: rotate(-45deg);
    transform: rotate(-45deg);
    -webkit-transition: all .2s linear;
    transition: all .2s linear;
}
.accordion p {
    margin: 0;
    padding: 10px 0;
    font-size: 13px;
}
.accordion .slide {
    padding: 0 15px;
}
.accordion .slide .slide {
    padding: 0 35px;
}
.accordion ul li {
    margin: 0 -15px;
    background: none;
    border-bottom: 1px solid #e5e7ea;
}
.accordion ul li:nth-child(2n) {
    background: none;
}
.accordion ul li:hover > a,
.accordion ul li.active > a {
    background: #fcb13b;
    color: #333;
}
.accordion ul a {
    padding: 9px 35px;
    color: #333;
}
.accordion-holder {
    padding: 20px 0 0;
}
.logo-holder {
    display: block;
    text-align: center;
    float: left;
}
.logo {
    display: inline-block;
    vertical-align: top;
    width: 191px;
    height: 53px;
    margin: 0 0 10px 0;
}
.logo img {
    display: block;
    width: 80%;
    margin: 0 auto;
}
.archive-page #header {
    padding-left: 20px;
    padding-right: 30px;
}
.archive-page #header .panel {
    margin-left: -30px;
    padding: 18px 35px 24px 54px;
}
.archive-page #header .panel strong {
    color: #ec8026;
}
.archive-page .visual-holder {
    margin: -47px 0 10px;
}
.archive-page .visual-box {
    border-color: #f0ece9;
    margin: 0 0 14px;
    padding: 12px;
    box-shadow: 1px 2px 2px rgba(0, 0, 0, .4), inset 1px 2px 2px rgba(0, 0, 0, .4);
    display: block;
}
.archive-page .visual-text strong {
    color: #8D1F1B;
    margin: 0 0 17px;
}
.archive-page .visual-text span {
    color: #000;
}
.subscription-page #header {
    padding-left: 20px;
    padding-right: 30px;
}
.subscription-page #header .panel {
    margin-left: -30px;
    padding: 18px 35px 24px 54px;
}
.subscription-page #header .panel strong {
    color: #ec8026;
}
.subscription-page h3 {
    font-size: 23px;
    margin: 0 0 15px;
}
.subscription-page .visual-holder {
    margin: -76px 0 10px;
}
.subscription-page .visual-text {
}
.js-tab-hidden {
    display: block !important;
    left: -9999px !important;
    position: absolute !important;
    top: -9999px !important;
}
.tabset {
    margin: 0 0 10px;
}
.tabset li {
    float: left;
    margin: 0 15px 0 0;
}
.tabset li:last-child {
    margin: 0;
}
.tabset a {
    display: inline-block;
    vertical-align: top;
    text-decoration: none;
    font-weight: bold;
    font-size: 17px;
    color: #697883;
    -webkit-transition: all .2s linear;
    transition: all .2s linear;
}
.tabset a.active {
    color: #374b5a;
}
.tabset a:hover {
    color: #8D1F1B;
    -webkit-transition: all .2s linear;
    transition: all .2s linear;
}
.tab-content .sub-title {
    text-transform: uppercase;
}
.tab-content .goto {
    text-decoration: none;
    color: #000;
}
.tab-content .goto:hover {
    color: #8D1F1B;
}
.tab-content .open-close-holder {
    margin: 0;
}
#footer {
    padding: 27px 0 40px;
    position: relative;
    background: white;
    z-index: 10;
}
#footer .holder {
    max-width: 1000px;
    padding: 0 50px;
    text-align: left;
}
#footer .column {
    display: block;
}
#footer .sitenav {
    margin: 30px 0 30px 40px;
}
#footer .sitenav li {
    display: block;
    margin: 18px 0 0;
}
#footer .sitenav li:first-child {
    margin: 0;
}
#footer .sitenav a, #footer .sitenav.rightsite  {
    display: inline-block;
    vertical-align: top;
    text-decoration: none;
    font-weight: bold;
    color: #000;
    font-size: 16px;
    -webkit-transition: all .2s linear;
    transition: all .2s linear;
}
#footer .sitenav.leftsite  {
    float: left;
}
#footer .sitenav a:hover {
    color: #8D1F1B;
    -webkit-transition: all .2s linear;
    transition: all .2s linear;
}
#footer .sitenav.rightsite  { 
    float: right;
    font-size: 12px;
    color: #c6c6c6;
    margin-right: 45px;
}
#footer .copyright {
    display: block;
    border-top: 1px solid #d3d8df;
    border-bottom: 1px solid #d3d8df;
    color: #5c6d89;
    font-size: 14px;
    font-weight: bold;
    padding: 26px 0;
    margin: 0 0 30px;
}
#footer .footer-logo {
    display: inline-block;
    vertical-align: top;
    width: 159px;
    height: 44px;
}
#footer .footer-logo img {
    display: block;
    vertical-align: top;
}
.fsp-wrapper A {
    color: #8D1F1B;
    text-decoration: none;
}
.fsp-wrapper {
    border: 7px solid #5E1619;
}
.fsp-content {
    width: 90%!important;
    height: 70%!important;
    top: 19%!important;
    left: 7%!important;
    margin: 0!important;
}
.fsp-close {
    font-size: 3em;
}
.visual-white .name-noshow {
    display: none;
}

@media only screen and (-webkit-min-device-pixel-ratio: 1.5), only screen and (min--moz-device-pixel-ratio: 1.5), only screen and (min-device-pixel-ratio: 1.5) {
    #fancybox-loading,
    .fancybox-close,
    .fancybox-prev span,
    .fancybox-next span {
        background-image: url("http://image.medicalupdate.novartis.at/lib/fe9213737762077f73/m/1/1ead60cd-e777-4445-b76f-19b192e2effa.png");
        background-size: 44px 152px; /*The size of the normal image, half the size of the hi-res image*/
    }
    #fancybox-loading div {
        background-image: url("../images/fancybox_loading@2x.gif");
        background-size: 24px 24px; /*The size of the normal image, half the size of the hi-res image*/
    }
}
@media (min-width: 480px) {
    .logo-holder {
    }
    .logo {
        width: 150px;
        height: 42px;
    }
}
@media (min-width: 768px) {
    .jcf-select {
        height: 65px;
        max-width: 105px;
    }
    .jcf-select .jcf-select-text {
        line-height: 62px;
        font-size: 18px;
        margin: 0 25px 0 18px;
    }
    .jcf-select .jcf-select-opener {
        width: 39px;
    }
    .jcf-list .jcf-option {
        font-size: 15px;
    }
    .slick-list {
        margin: 0 -33.5%;
    }
    .slick-holder {
        margin: 0 -35px 35px;
    }
    #wrapper {
        z-index: 2;
    }
    .visual .holder {
        padding: 0;
        padding-left: 70px;
    }
    .visual-holder {
        display: inline-block;
        vertical-align: top;
        width: 350px;
        margin-top: -67px;
    }
    .visual-holder .btn-holder {
        display: block;
        position: absolute;
        z-index: 10;
        top: 0;
        right: 58px;
        top: 33px;
    }
    .content-holder {
        display: inline-block;
        vertical-align: top;
        width: calc(100% - 355px);
        padding: 20px;
    }
    #nav {
        max-width: 345px;
        background: url(http://image.medicalupdate.novartis.at/lib/fe9213737762077f73/m/1/6a32701c-5f1f-4a33-bc24-4ac079eda23e.png) no-repeat;
        background-size: cover;
        padding-bottom: 70px;
        border-radius: 0 8px 0 0;
        overflow: hidden;
    }
    .nav-drop .ico-holder {
        max-width: 60px;
    }
    .nav-drop {
        position: static;
        visibility: visible;
        opacity: 1;
        height: auto;
        background: transparent;
        border: none;
        padding: 0;
        min-height: 0;
    }
    .nav-drop li {
        display: block;
        border-top: none;
    }
    .nav-drop a {
        padding: 15px 5px 15px 18px;
    }
    .link-text {
        max-width: 265px;
        min-width: 265px;
    }
    .nav-opener {
        display: none;
    }
    .slideshow-top .slide {
        padding: 46px 50px 70px;
    }
    .slideshow-top .slide-text {
        font-size: 21px;
        text-align: left;
    }
    .btn-next,
    .slick-next,
    .btn-prev,
    .slick-prev {
        bottom: auto;
        top: 50%;
        left: 35px;
        -webkit-transform: translateY(-50%);
        -ms-transform: translateY(-50%);
        transform: translateY(-50%);
    }
    .btn-next:before,
    .slick-next:before,
    .btn-prev:before,
    .slick-prev:before {
        width: 24px;
        height: 24px;
        border-width: 4px;
    }
    .btn-next,
    .slick-next {
        left: auto;
        right: 58px;
    }
    .content-section .holder {
        padding-top: 56px;
    }
    .content-section .img-holder {
        float: left;
        margin: 0 30px 0 0;
    }
    .popup-holder {
        float: right;
        margin-left: 50px;
    }
    .add-info-box {
        font-size: 21px;
        line-height: 25px;
        padding: 26px 20px 25px 62px;
        margin-bottom: 45px;
    }
    .content-block {
        margin-bottom: 63px;
    }
    .description {
        display: -webkit-box;
        display: -webkit-flex;
        display: -ms-flexbox;
        display: flex;
    }
    .description-content {
        display: -webkit-box;
        display: -webkit-flex;
        display: -ms-flexbox;
        display: flex;
        -webkit-box-orient: vertical;
        -webkit-box-direction: normal;
        -webkit-flex-direction: column;
        -ms-flex-direction: column;
        flex-direction: column;
        width: 55%;
    }
    .bottom-section .holder {
        padding: 45px 20px 0;
    }
    .bottom-section h3 {
        margin: 0 0 28px;
    }
    .bottom-section .opener {
        padding: 25px 90px 24px 33px;
        font-size: 16px;
    }
    .bottom-section .opener:after,
    .bottom-section .opener:before {
        right: 30px;
    }
    .bottom-section .opener em {
        width: 83px;
    }
    .open-close .slide {
        padding: 5px 100px 5px 30px;
        line-height: 24px;
    }
    .open-close .slide p {
        margin: 0 0 28px;
    }
    .open-close.active .opener {
        background: #fff;
        border-bottom: none;
    }
    .open-close-holder.literatur .opener {
        padding: 25px 90px 24px 33px;
        font-size: 16px;
    }
    .open-close-holder.literatur .slide {
        padding-top: 3px;
        line-height: 20px;
        padding-bottom: 15px;
    }
    .open-close-holder.literatur .slide ol li {
        margin: 0 0 10px;
    }
    .subscription-form p {
        margin: 0 0 15px;
        line-height: 25px;
    }
    .subscription-form .inner-box {
        margin: 0 0 27px;
    }
    .subscription-form .submit-holder {
        text-align: right;
        padding: 6px 0 0 0;
    }
    .subscription-form .sub-title {
        line-height: 25px;
        margin: 0 0 28px;
    }
    .subscription-form .row-holder {
        margin: 0 -11px 0 0;
    }
    .subscription-form .row.small {
        width: 21%;
    }
    .subscription-form .row.medium {
        width: 35%;
    }
    .subscription-form .row.large {
        width: 96%;
    }
    .subscription-form .row.m25 {
        width: 24%;
    }
    .subscription-form .row.m40 {
        width: 35%;
    }
    .subscription-form .row.m50 {
        width: 47%;
    }
    .subscription-form .row.m60 {
        width: 59%;
    }
    .subscription-form .row.m75 {
        width: 73%;
    }
    .subscription-form .row {
        display: inline-block;
        vertical-align: top;
        margin: 0 11px 30px 0;
    }
    .subscription-form label {
        margin: 0 0 10px;
    }
    .subscription-form .text:focus {
        box-shadow: 0 0 7px rgba(69, 115, 141, .27);
    }
    .subscription-form .text {
        font-size: 18px;
        line-height: 23px;
        padding: 7px 19px;
    }
    .subscription-form .text:focus {
        box-shadow: 0 0 7px rgba(69, 115, 141, .27);
    }
    .listdescription {
        font-size: 18px;
        display: inline-block;
    }
    .subscription-form .row-check .fake-input, #weitereinfos .fake-input{
        width: 26px;
        height: 26px;
        margin-right: 11px;
    }
    .subscription-form .row-check  .link {
        color: #8D1F1B;
        cursor: pointer;
        font-weight: 500;
        display: inline-table;
        font-size: 18px;
    }
    .subscription-form .row-check .link:hover {
        text-decoration: underline;
    }
    .subscription-form .row-check .fake-label {
        font-weight: 500;
    }
    .subscription-form .row-check [type="checkbox"] + .fake-input:before {
        width: 19px;
        height: 18px;
        margin: -9.5px 0 0 -9px;
    }
    #weitereinfos [type="checkbox"] + .fake-input:before {
        width: 19px;
        height: 18px;
        margin: -9.5px 0 0 -9px;
    }
    .subscription-form .row-check {
        margin: 0 0 18px;
    }
    .subscription-form .row.holder.lastrow {
        width:100%;
        margin: 30px 0;
        padding: 0;
    }
    .subscription-form .submit {
        display: inline-block;
        width: auto;
        padding: 10px 101px;
    }
    .subscription-form {
        padding: 127px 80px 16px 40px;
    }
    .preferencesPage.subscription-form {
        padding: 72px 80px 16px 40px;
    }
    .pbold {
        font-weight: bold;
        font-size: 18px;
    }
    .archive-holder p {
        line-height: 25px;
        margin: 0 0 17px;
    }
    .archive-holder h3 {
        font-size: 27px;
    }
    .accordion li.active a:after {
        right: 36px;
    }
    .accordion li.active a:before {
        right: 26px;
    }
    .accordion li.active ul a:after {
        width: 14px;
        height: 3px;
        background: #999 !important;
        right: 30px;
        margin: -5px 0 0;
    }
    .accordion li.active ul a:before {
        width: 14px;
        height: 3px;
        background: #999 !important;
        right: 30px;
        margin: 4px 0 0;
    }
    .accordion a:after {
        width: 17px;
        height: 4px;
        right: 30px;
        margin: -5px 0 0;
    }
    .accordion a:before {
        width: 17px;
        height: 4px;
        right: 30px;
        margin: 4px 0 0;
    }
    .accordion a {
        font-size: 16px;
        padding: 18px 32px 17px 32px;
    }
    .accordion p {
        font-size: 16px;
        line-height: 25px;
    }
    .accordion .slide {
        padding: 0 32px;
    }
    .accordion .slide .slide {
        padding: 0 84px;
    }
    .accordion ul li {
        margin: 0 -32px;
    }
    .accordion ul a {
        padding: 9px 84px;
    }
    .accordion-holder {
        padding: 25px 0 0;
    }
    .logo {
        width: 191px;
        height: 53px;
    }
    .archive-page .visual-holder {
        margin: -127px 0 10px;
    }
    .archive-page .visual-box {
        padding: 59px 34px 25px;
    }
    .subscription-page h3 {
        font-size: 27px;
        margin: 0 0 28px;
    }
    .subscription-page .visual-holder {
        margin: -109px 0 0;
    }
    .subscription-page .visual-box {
        padding: 23px 34px 25px;
    }
   .PersonalLocation.subscription-page  P{
       padding-left: 0; 
    } 
    .tabset {
        margin: 0 0 27px;
    }
    .tabset li {
        margin: 0 55px 0 0;
    }
    .tabset a {
        font-size: 27px;
    }
    #footer .holder {
        padding: 0 28px;
    }
    #footer .sitenav li {
        float: left;
        margin: 0 20px 0 0;
        position: relative;
    }
    #footer .sitenav li:first-child {
        margin: 0 20px 0 0;
    }
    #footer .sitenav li:first-child:after {
        display: none;
    }
    #footer .sitenav li:last-child {
        margin: 0;
    }
    #footer .sitenav a {
        color: #000;
        font-size: 14px;
    }
    #footer .copyright {
        padding: 12px 0;
        border-bottom: 0;
        text-align: left;
        color: #000;
    }
    #footer {
        padding: 33px 0 40px;
        box-shadow: none;
        z-index: 1;
    }
}
@media (min-width: 769px) {
    .archive-page #header {
        padding-right: 55px;
    }
    .subscription-page #header {
        padding-right: 55px;
    }
}
@media (min-width: 1000px) {
    .slick-holder {
        margin: 0 -55px 55px;
    }
    #wrapper {
        border-radius: 0;
    }
    .left {
    }
    .visual-grey {
        margin: 0;
    }
    .visual-holder .btn-holder {
        top: 83px;
    }
    .visual-holder .btn-holder a {
        padding: 7px 20px 5px;
    }
    .content-holder {
        padding-left: 48px;
    }
    .visual-box {
        padding: 113px 30px 25px;
        margin: 0 0 60px;
    }
    .visual-text {
        width: 100%;
        font-size: 21px;
    }
    .visual-text strong {
        font-size: 30px;
        margin: 0 0 25px;
    }
    .title {
        padding-bottom: 8px;
    }
    .title h1 {
        letter-spacing: 3px;
    }
    .slideshow-top .slide {
        padding-top: 105px;
        min-height: 355px;
    }
    .slideshow-top .slide-text {
        line-height: 32px;
    }
    .pagination,
    .slick-dots {
        bottom: 32px;
    }
    .pagination li,
    .slick-dots li {
        width: 15px;
        height: 15px;
    }
    .add-info-box.large {
        padding-right: 30px;
        margin-bottom: 55px;
    }
    .description .img-holder {
        width: 37%;
    }
    .description-content {
        width: 63%;
        padding: 20px 40px 20px 55px;
    }
    .content-row li {
        padding-left: 28px;
    }
    .content-row li:before {
        left: 11px;
    }
    .logo img {
        width: 100%;
    }
    .subscription-page .visual-holder {
        margin: -127px 0 0;
    }
    .PersonalLocation.subscription-page P{
       padding-left: 0; 
    } 
    .overview-page .visual-box {
        margin: 0 0 44px;
        padding: 113px 30px 16px;
    }
    #footer .column {
        float: left;
    }
    #footer .column:first-child {
        float: left;
        max-width: 80%;
    }
}
@media only screen and (min-width: 1025px) {
    a[href^=tel],
    a[href^=skype],
    a[href^=sms] {
        cursor: default;
        pointer-events: none;
    }
}
@media (max-width: 1244px) {
    .visual-text p {
        line-height: 27px;
        font-size: 25px;
    }
    .left h1 {
        font-size: 25px; 
        line-height: 30px;
    }
    .visual-brown {
        width: 100%;
        left:0;
    }
    .listdescription {
        font-size: 17px;
    }
    .visual-white form {
        padding-left:0;
    }
    .preferencesPage.subscription-form {
        padding-right:  16px;
        padding-top:  60px;
    }
}
@media (max-width: 1080px) {
    #footer .sitenav.leftsite {
        margin: 15px;
    }  
    #footer .sitenav.rightsite {
        float: left;
        margin: 15px;
    }  
    #footer .sitenav {
        margin: 15px;
    }
    #footer {
        text-align: center;
    }
    .subscription-form label  {
        font-weight: 600;
        font-size: 16px;
    }
    .subscription-form .row-check .link  {
        font-size: 16px;
    }
    .right.wife {
        width: 80%;
    }
    .left.wife {
        width: 18%;
   }
    .PersonalLocation.subscription-form P {
        padding-left: 0;
    }
    .listdescription {
        font-size: 16px;
    }
}
@media (max-width: 767px) {
    .visual {
        background-position-y: bottom;
    }
    .visual .holder {
        display: none;
    }
    .left, .right, .left.wife, .right.wife {
        float: none;
        width: 98%
    }
    .holder {
        padding: 0;
        margin: 0;
    }
    .right, .right.wife {
        margin-top: 0;
        width: 100%;
    }
    .holder.little {
        display: block!important;
        background-color: #5E1619;
        visibility: visible;
    }
    .row-holder.clearfix {
        margin-top: 37px;
    }
    .left, .left.wife {
        display: none;
    }
    .pbold {
        font-weight: 600;
        font-size: 16px;
    }
    .fake-label {
        font-weight: 500;
    }
    .subscription-form .row-check  .link {
        color: #8D1F1B;
        cursor: pointer;
        font-weight: 500;
        display: inline-table;
        font-size: 18px;
    }
    .subscription-form .row-check .link:hover {
        text-decoration: underline;
    }
    .visual-brown {
        color: black;
        background-color: white;
        position: initial;
    }
    .right.wife .visual-brown h3 {
    color: black;
    padding: 30px;
    
}  
    .visual-text p {
        color: black;
        font-size:27px;
        line-height: 27px;
        margin-left:20px;
    }

    .visual-text {
        padding: 30px 5px;
    }
    .subscription-form {
        padding:10px;
        margin: 10px;
    }
    .preferencesPage.subscription-form .row-check label{
        display: block;
    }
    .preferencesPage.subscription-form {
        margin:0;   
        padding-top: 0;

    }
    .visual-white .preferencesPage form {
        padding: 10px 2px;
        width: 98%;
    }
    .preferencesPage.subscription-form .row.small, .preferencesPage.subscription-form .row.medium, .preferencesPage.subscription-form select  {
        width: 100%;
    }
    .PersonalLocation.subscription-form {
        margin:0;   
        margin-left: 2px;
        padding-top: 0px;
        padding: 0 10px 10px 10px;
    }
    .PersonalLocation.subscription-form P.onlyonce {
        margin-left: 0;
        padding-left: 0;
    }
    .right.wife   .visual-text {
        padding: 20px;
        width: 100%;
        text-align: center;

    }
    .subscription-page .visual-white h3 {
        font-size: 26px;
    }
    .subscription-page .visual-white h3, .subscription-page .visual-white p {
        padding: 10px;
        margin: 10px;

    }
    .subscription-page .visual-white p.clink {
        position: initial;
    }
    .borderwhite {
        padding-bottom: 0;
        padding-top: 10px;
        margin-bottom: 15px;
    }
    .fsp-wrapper h1 {
        font-size: 1.5em;
        line-height: 25px;
    }
    .fsp-wrapper p {
        font-size: 13px;
    }
    .fsp-wrapper div {
        margin-bottom: 30px;
    }
    .fsp-content {
        top: 8%!important;
    }
    .mejs-overlay-button {
        width: 50px;
        height: 50px;
        background: url(http://image.medicalupdate.novartis.at/lib/fe9213737762077f73/m/1/5f2c5e33-fb35-4775-be8b-e1b298666476.png) no-repeat;
        margin: -25px 0 0 -25px !important;
        background-size: cover;
    }
    .mejs-controls .mejs-fullscreen-button button {
        margin: 10px 5px 6px;
    }
    .slick-arrow:before {
        border-color: #fff !important;
        overflow: hidden;
    }
    .slick-dots {
        bottom: 20px !important;
    }
    .description .img-holder {
        display: none;
    }
    #footer .sitenav {
        margin: 0px 0 0 20px;
    }
    #footer .sitenav.leftsite {
        float: none;
    }
    #footer .sitenav.rightsite {
        float: none;
    }
}
@media (max-width: 500px) {
}
.clearfix {
    clear: both;
}
@-webkit-keyframes buffering-stripes {
    from {
        background-position: 0 0;
    }
    to {
        background-position: 30px 0;
    }
}
@keyframes buffering-stripes {
    from {
        background-position: 0 0;
    }
    to {
        background-position: 30px 0;
    }
}